منابع مشابه
"Aspartame: A review of genotoxicity data".
Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200× sweeter than sucrose and is approved for use in food products in more than 90 countries around the world. Aspartame has been evaluated for genotoxic effects in microbial, cell culture and animal models, and has been subjected to a number of carcinogenicity studies. The in vitro and in vivo genotoxicity dat...
متن کاملGenotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin.
Low-calorie sweeteners are chemicals that offer the sweetness of sugar without the calories. Consumers are increasingly concerned about the quality and safety of many products present in the diet, in particular, the use of low-calorie sweeteners, flavorings, colorings, preservatives, and dietary supplements. In the present study, we evaluated the mutagenicity of the three low-calorie sweeteners...
متن کاملAspartame: review of safety.
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. Its safety was further confirmed through studies in several human subpopulations, includin...
متن کاملMetabolism of aspartame in monkeys.
Aspartame (SC-18862, 3-amino-N-(a-carboxyphenethyl)succinarnic acid, methyl ester; the methyl ester of aspartyl-phenylalanine ) is a sweetening agent that organoleptically has about 180 times the sweetness of sugar. Because it so closely resembles naturally occurring dipeptides, it was believed that it would be digested in a similar manner. To show this, the metabolism of [14C]aspartame labeled...
متن کاملAspartame m a review
Aspartame (APM), a newly available synthetic sweetener approximately 180-200 times sweeter than sucrose, was approved for marketing by the FDA in 1981 following several years of scientific review. It is available in the United States for use as a sweetener in breakfast cereals, powdered beverages, gelatins, puddings, fillings, whipped toppings, chewing gum, soft drinks and as a table-top sweete...
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ژورنال
عنوان ژورنال: Drug and Chemical Toxicology
سال: 2004
ISSN: 0148-0545,1525-6014
DOI: 10.1081/dct-120037506